The total, free and complexed PSAs increased with age (linear trend, p < 0.001), but the percent free and complexed PSA and the free/complexed PSA did not change significantly with age. Total PSA GM increased from 0.74 μg/l, for men 40-49 years, to 1.82 μg/l for men 80 years and older. These molecular differences explain the possibility to distinguish free from total PSA (F/T ratio). Free and complexed PSA have different clearances and significant differences between clearance of free PSA after radical prostatectomy (RP) and after open surgery for benign prostatic hyperplasia (BPH) are observed. The ease of calibration and the accuracy of free PSA assays in comparison with assays of the PSA-ACT complex suggest that measurements of free to total PSA most accurately reflect the inverse of the proportion of PSA complexed to ACT in serum. Many studies have explored the effect of free/total prostate-specific antigen (f/t PSA) ratio in monitoring prostate cancer. We conducted a meta-analysis to identify the accuracy of the f/t PSA ratio in the diagnosis of prostate cancer in patients who have PSA levels of 4 to 10 ng/mL. Over the past years, the assessment of equimolarity has been typically performed by the characterization of the recovery of IS 96/670, consisting of 90% PSA-ACT and 10% PSA free form, by marketed PSA assays. Correlation between the complex PSA/total PSA ratio and the free PSA/total PSA ratio, sensitivity and specificity of both markers for the diagnosis of prostate cancer Correlación del cociente PSA complex/PSA total con el cociente PSA libre/PSA total, sensibilidad y especificidad de ambos marcadores para el diagnóstico del cáncer de prostata☆ e2I2u.

complexed psa vs free psa